We will address these questions using cutting edge technologies and new tools and procedures we already setup. Lastly, we will translate our analysis to human OCLs. The overall aim of our project is to characterize the diversity of murine OCLs at the phenotypic and functional level, to determine their origin and their contribution to physiological bone resorption or pathological bone destruction, in order to identify how they could be targeted to limit inflammatory bone destruction. Our preliminary data strongly support this hypothesis.
In particular recent data including from our consortium suggested that inflammatory bone destruction would not only rely on increased OCL differentiation but also on the emergence during the disease course of new OCL subsets having the capacity to modulate or exacerbate inflammation. However the mechanisms of inflammatory bone destruction are not well understood. This is attributed to an overproduction of OCL-stimulating factors by activated immune cells. It is also often observed when inflammation is far from the bone such as in inflammatory bowel disease. The aim of the DIVOS project is to characterize this diversity both in normal and pathological conditions related to osteoporosis, Crohn's disease and rheumatoid arthritis.īone destruction by osteoclasts (OCLs) is a hallmark of osteoporosis and chronic inflammatory diseases such as rheumatoid arthritis (RA). Recent works, including from our consortium, have highlighted a still unknown diversity of osteoclasts at both phenotypic and functional levels. Osteoclasts are the cells responsible for this bone destruction. It leads to an increased risk of fracture, deterioration of quality of life and increased mortality, and new therapeutic options are still needed. Osteoclast diversity in chronic inflammation: towards new therapeutic options for bone destruction Context and objectiveīone destruction is a characteristic of chronic inflammatory diseases such as osteoporosis, rheumatoid arthritis or Crohn's disease. CE14 - Physiologie et physiopathologie Diversity of osteoclasts in chronic inflammation: towards new therapeutic options for bone destruction – DIVOS Osteoclast diversity, towards new therapeutic options for bone destruction
0 kommentar(er)
